Michael K. Rosen received B.S. and B.S.E. degrees in Honors Chemistry and Chemical Engineering from the University of Michigan in 1987. He was a Winston Churchill Foundation Scholar in Allen Battersby’s laboratory at the University of Cambridge in 1987-8. He received his Ph.D. in 1993 from Stuart Schreiber’s laboratory in the Harvard Chemistry Department for structural and biochemical studies of FKBP12. He was a Damon Runyon-Walter Winchell postdoctoral fellow in the laboratories of Lewis Kay and Tony Pawson at the University of Toronto and the Samuel Lunenfeld Research Institute from 1993-1995. There he studied autoinhibition of the Crk protein and developed methods for selective methyl group labeling of proteins in a deuterated background, enabling NMR studies of large macromolecules. Rosen began his independent laboratory in the Cellular Biochemistry and Biophysics Program at the Memorial Sloan-Kettering Cancer Center, and Department of Biochemistry and Structural Biology at Weill Cornell Medical College in 1996. He joined the Department of Biochemistry at UT Southwestern Medical Center in 2001, and was elected into HHMI in 2005. In 2012 he was named the inaugural Chair of the Department of Biophysics, and holds the Mar Nell and F. Andrew Bell Chair in Biochemistry. Rosen uses biophysical techniques to discover principles of cellular organization. His early work elucidated physical mechanisms underlying Rho GTPase signaling pathways that control actin dynamics, establishing general principles of allostery and signal integration. Since 2009 he has studied macromolecular liquid-liquid phase separation and biomolecular condensates, eukaryotic cell compartments that concentrate macromolecules without an encapsulating membrane. His work has informed on the formation, regulation, composition and function of phase separated compartments in vitro and in cells. For this work he was awarded the 2019 Wiley Prize, and in 2020 was elected into the U.S. National Academy of Sciences.